MICROFLUIDIC SPERM SORTER TECHNIQUE
Microfluidic Sperm Sorter technique is a boon to the couples facing difficulty in achieving parenthood due to male factor infertility. It is a game changing revolutionary technology where highly motile and structurally normal spermatozoa with good DNA integrity are separated from semen so that they can be used to fertilize oocytes.
This technique is based on a principle called ‘Microfluidics’. It is observed that physiologically and genetically perfect sperms exhibit a high grade of forward motility. In this technique, an embryologist takes advantage of this property of sperms. In a simplified way, the sperms are made to race in a narrow stream of fluid. The heathiest sperms win this race and get collected in a specific chamber. Those sperms are separated and used to fertilize ovum by ICSI process.
This technique is extremely helpful in the cases where the male partner has deficient amount of structurally normal sperms (teratozoospermia) or where sperms show a higher DNA fragmentation index (DFI). Patients in whom good quality embryos were not formed or IVF failed in previous cycle despite of a normal semen analysis report, may also opt for this technique.
The main advantage of this technique is its ability to yield morphologically normal sperms with intact DNA devoid of dead sperms or any debris that can be used in an IVF cycle. Research has proven that use of Microfluidics Sperm Sorter technique leads to higher fertilization rate, formation of better embryos as well as increase in pregnancy rates after ICSI procedure.
NON- INVASIVE PREIMPLANTATION GENETIC TESTING (NIPGT-A)
The Non-invasive Preimplantation genetic testing, also called niPGT is an upcoming, innovative and promising technology that does not require a fetal biopsy and facilitates access to the control of chromosomal abnormalities in the embryo during IVF cycle.
In the early days of PGT-A, the challenge of science was to be able to control the genetic makeup of embryos without having to biopsy their cells. In recent years, research in this area has intensified and several genetics laboratories have already developed platforms for the analysis of chromosomal abnormalities at the blastocyst stage from alternative sources of their cellular DNA. This is a genetic analysis carried out on the free DNA contained in the culture material where the embryos develop as part of in vitro fertilization.
It will help in improving the IVF outcomes in patients with advanced age, recurrent miscarriages, recurrent IVF failures and patients with genetic disorders. Hence, this technique should definitely be offered to these categories of patients in order to improvise their success rate.
This procedure is expected to become a reality in the near future. It is an exciting prospect, since it would not require a fetal biopsy and would facilitate proper control over the chromosomal abnormalities in the embryo during IVF cycle. If so, the niPGT would be non-invasive, precise and inexpensive.
This technique will definitely be advantageous for those couples with advanced age because it has been observed that as many as 50 percent of grade 1 embryos might not be genetically normal, so when we select them according to their ploidy status, we can improve the IVF outcome and can give them a healthy pregnancy. Also, the patient will be able to go for a single embryo transfer without compromising the success and hence we can reduce the burden of multiple pregnancies and the complications associated with it.
The Visionary of Dr. Iram’s IVF Maternity & Laparoscopic Hospital
Dr. Iram, Director of the hospital
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